Endocrine Abstracts

Increased need for thyroxine has been described in several gastrointestinal disorders (H. pylori infection, gastric atrophy, celiac disease), even in their occult or symptomless forms. A transitory or stable impairment of gastric acidity, by increasing pH value, seems to interfere with thyroxine availability, highlighting a novel role for the stomach in the following intestinal T4 absorption. Distinctive dissolution profiles of different T4 prepara...